Daughter of Francis Exavier Downs and Elizabeth Wimsatt, she married Lewis Washington Greenwell on 6 Apr 1830 in Nelson Co., Kentucky. Mother of John Roseman Greenwell, Mary Elizabeth Greenwell Ballard, Mary Catherine "Kate" Greenwell Newton, James Henry Greenwell, James P. "Jim" Greenwell, Frances Ann "Fanny" Greenwell Downs, Mary Downs Greenwell Ballard, William Washington "Billy" Greenwell and Eliza Jane Greenwell Clark.

Charles Donatus "Pappy" Cecil had knowledge of her date of death and that she was buried in St. Thomas Cemetery.